Serotonin-dependent respiratory plasticity
نویسندگان
چکیده
منابع مشابه
Cervical dorsal rhizotomy increases brain-derived neurotrophic factor and neurotrophin-3 expression in the ventral spinal cord.
Although neurotrophic factors have been implicated in several forms of neuroplasticity, little is known concerning their potential role in spinal plasticity. Cervical dorsal rhizotomy (CDR) enhances serotonin terminal density near (spinal) phrenic motoneurons and serotonin-dependent long-term facilitation of phrenic motor output (Kinkead et al., 1998). We tested the hypothesis that selected neu...
متن کاملPhysiological and Genomic Consequences of Intermittent Hypoxia Invited Review: Intermittent hypoxia and respiratory plasticity
Mitchell, Gordon S., Tracy L. Baker, Steven A. Nanda, David D. Fuller, Andrea G. Zabka, Brad A. Hodgeman, Ryan W. Bavis, Kenneth J. Mack, and E. B. Olson, Jr. Invited Review: Intermittent hypoxia and respiratory plasticity. J Appl Physiol 90: 2466–2475, 2001.— Intermittent hypoxia elicits long-term facilitation (LTF), a persistent augmentation (hours) of respiratory motor output. Considerable r...
متن کاملThe distribution of serotonin-immunoreactive cells in larynx, trachea and bronchi of goat (Capra aegagrus) and bovine (Bos taurus)
The respiratory tract contains numerous peptides secreted from special pulmonary epithelial cells whichare called endocrine cells. The function of neuroendocrine cells is modulated by amines. Serotonin has strong vasomotor and bronchomotor effects in the airway mucosa. The objective of this study was to determine presence and distribution of serotonin-positive endocrine cells in respiratory tra...
متن کاملIntermittent hypercapnia-induced phrenic long-term depression is revealed after serotonin receptor blockade with methysergide in anaesthetized rats.
NEW FINDINGS What is the central question of this study? Intermittent hypercapnia is a concomitant feature of breathing disorders. Hypercapnic stimuli evoke a form of respiratory plasticity known as phrenic long-term depression in experimental animals. This study was performed to investigate the putative role of serotonin receptors in the initiation of phrenic long-term depression in anaestheti...
متن کاملCervical dorsal rhizotomy enhances serotonergic innervation of phrenic motoneurons and serotonin-dependent long-term facilitation of respiratory motor output in rats.
We tested the hypothesis that spinal plasticity elicited by chronic bilateral cervical dorsal rhizotomy (C3-C5; CDR) has functional implications for respiratory motor control. Surgery was performed on rats (CDR or sham-operated) 26 d before phrenic motoneurons were retrogradely labeled with cholera toxin. Rats were killed 2 d later, and their spinal cords were harvested and processed to reveal ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2001